John Condeelis, PhD

Judith & Burton P. Resnick Chair in Translational Research

Professor and Co-Chair,

Department of Anatomy and Structural Biology

Professor of Surgery,

Director, Basic and Translational Research,

Department of Surgery

Co-Director, Gruss Lipper Biophotonics Center &

Integrated Imaging Program

Scientific Director, Analytical Imaging Facility

Co-Director, Tumor Microenvironment and Metastasis Program, Albert Einstein Cancer Center

Albert Einstein College of Medicine

Dr. Condeelis expertise is in optical physics (1), surgical engineering (1), cancer biology (2) and mouse models (3a-b), and the development of prognostics of metastasis (4). He and his research collaborators developed the custom built multiphoton imaging technology, surgically implanted imaging windows, and animal models used to identify the invasion and intravasation microenvironments in breast tumors and their metastatic sites. This led to the discovery of the paracrine interaction between tumor cells and macrophages in vivo, and the role of macrophages in the migration of tumor cells and intravasation in primary and metastatic tumors. This led to the discovery of the mouse and human invasion signatures which have supplied markers for the prediction of breast tumor metastasis in humans. These markers are being clinically validated and some are now in clinical use (4).

Dr. Condeelis received awards in recognition of this work including Elected Fellow of the American Association for the Advancement of Science, Horwitz Prize for Research Excellence, and the Metastasis Research Society - I.J. "Josh" Fidler Innovation in Metastasis Research Award.

He has a long training record of mentoring students, clinical fellows and post-doctoral fellows, junior faculty and have taught numerous courses in optics, histology, general biology, cancer and cell biology and physiology. In the past 10 years he has mentored 26 post-doctoral fellows and 16 Ph.D. and M.D./Ph.D. students and 8 clinical fellows, and 10 junior faculty (5). He was awarded the Einstein Junior Faculty Mentoring Award. I have collaborated extensively with basic scientists and clinicians in the Albert Einstein Cancer Center and support all of their research through my Directorship of the Tumor Microenvironment and Metastasis program in the Albert Einstein Cancer Center.