Session date: 
Wednesday, October 16, 2019 - 12:00pm to 1:00pm

Davide Ruggero Ph.D

Professor

Helen Diller Family Endowed Chair in Basic Research

University of California San Francisco (UCSF)

School of Medicine and Department of Urology

Member, UCSF Comprehensive Cancer Center

 

Dr. Davide Ruggero, Ph.D., is a Professor in the Department of Urology and Cellular & Molecular Pharmacology, he holds the Helen Diller Family Endowed Chair of Basic Cancer Research at the University of California, San Francisco (UCSF). Dr. Ruggero has made numerous breakthrough discoveries in the area of mammalian translational control as well as how deregulation in translation control leads to cancer, establishing a new field of study. Dr. Ruggero uncovered that deregulations in translation control serves as a common mechanism downstream of multiple oncogenic signals (e.g. PI3K-AKT-mTOR, Ras, Myc) to cause cellular transformation. Genome-wide analysis of the deregulated proteome during cancer formation utilizing novel polysome microarrays and ribosome profiling pioneered by the Ruggero lab indicates that control of protein production provides a highly specific, robust, and rapid response to oncogenic stimuli. The Ruggero lab complemented these studies by generating the first mouse models for components of the translation machinery found mutated in human disease and cancer. Utilizing biochemical, molecular, and genetic approaches within the context of these unique animal models, Dr. Ruggero are uncovering novel mechanisms for gene-specific control of mRNA translation vital for cancer initiation. These results have been instrumental in the design of a new generation of compounds that modulate protein synthesis and act as novel therapeutic agents.

Location: 
Bluemle Life Sciences Building
233 South 10th Street
Conference Room 101
Philadelphia, PA 19107
United States
Session Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 Attendance

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