Session date: 
Wednesday, February 6, 2019 - 12:00pm to 1:00pm

Jean-Pierre Issa, MD

American Cancer Society Clinical Research Professor of Medicine

Director, Fels Institute for Cancer Research and Molecular Biology

Temple University School of Medicine

Dr. Issa received his undergraduate training and his M.D. from the American University of Beirut followed by residency in internal medicine at Good Samaritan Hospital and fellowship in Medical Oncology at the Johns Hopkins Oncology Center in Baltimore. He was on the faculty at Johns

Hopkins from 1994-1999, at the University of Texas M. D. Anderson Cancer Center from 1999-2011, and at Temple University School of Medicine from 2011, where he is currently Professor of

Medicine and Director, Fels Institute for Cancer Research and Molecular Biology.

Dr. Issas laboratory has made significant contributions to the understanding of epigenetics in the pathophysiology and treatment of cancer. Some of his lab’s discoveries include the effects of aging (1994) and inflammation (2000) on promoter DNA methylation, the CpG Island Methylator Phenotype (1999), methylation-independent gene silencing in cancer by Polycomb group proteins (2008), and a link between epigenetics and the microbiome in colon cancer (2014). Starting in

2000, his group initiated laboratory research directed clinical trials that showed that low doses of hypomethylating drugs specifically target DNA methylation and are optimal in the treatment of

leukemias. This work contributed to the FDA approval of decitabine in 2006, and led to a large

number of epigenetic therapy clinical trials in different malignancies. His current research focuses on mechanisms of epigenetic alterations in aging and cancer, translation of epigenomic studies for precision medicine, development of drugs for reprogramming the epigenome, and clinical trials of epigenetic therapy in cancer.

Dr. Issas research has been recognized by numerous awards including a Sidney Kimmell

Foundation Scholar Award in 1997, election to the American Society of Clinical Investigation in

2003, an American Cancer Society Clinical Research Professorship in 2007, the Faculty Achievement Award in Basic Research from MD Anderson in 2007, the Rosenthal Award from the American Association for Cancer Research in 2011, and election to the American Association of Physicians in 2015.

Location: 
Bluemle Life Sciences Building
233 South 10th Street
Conference Room 101
Philadelphia, PA 19107
United States
Session Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 Attendance

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