Daniel Gioeli, PhD
Dept. Microbiology, Immunology, and Cancer Biology
University of Virginia
Daniel Gioeli, PhD is an Associate Professor of Microbiology, Immunology, and Cancer Biology at the University of Virginia. Dr. Gioeli’s work on prostate cancer began with performing pioneering work using activation state specific antibodies to interrogate signaling in archival pathology samples to discover that MAPK activity increases as prostate cancer progresses to a castration resistant disease. Dr. Gioeli has also done significant work on the identification of the endogenous AR phosphorylation sites in prostate cancer cells to systematically explore regulated changes in AR phosphorylation as a possible mechanism for activation/sensitization of AR-dependent gene expression by cell surface receptors and associated downstream effectors. Dr. Gioeli’s research is currently focused on identifying signaling pathways that compensate for androgen deprivation therapy in prostate cancer.