David H. Ledbetter, PhD, FACMG – is Executive Vice President and Chief Scientific Officer at Geisinger Health System, a not-for-profit integrated health system in Pennsylvania and New Jersey. Dr. Ledbetter previously held academic and leadership positions at Emory University, the University of Chicago, the National Center for Human Genome Research at the National Institutes of Health, and Baylor College of Medicine. He is a graduate of Tulane University and earned his Ph.D. at the University of Texas-Austin. After his early discovery of the genetic causes of Prader-Willi syndrome (1981) and Miller-Dieker syndrome (1983), Dr. Ledbetter has focused his research efforts on discovering the underlying etiology of childhood neurodevelopmental disorders such as autism, and the translation of new genomics technologies into clinically useful genetic tests for early diagnosis and intervention. His current research interest includes leveraging longitudinal electronic health information with large-scale DNA sequencing to determine the clinical utility and cost-effectiveness of precision medicine approaches in a real-world health system setting.