Carlo M Croce，M.D.
Distinguished University Professor
The John W. Wolfe Chair in Human Cancer Genetics
The Ohio State University, Columbus, Ohio, USA
Carlo M. Croce, MD, is the Professor and Chair of Molecular Virology, Immunology and Medical Genetics, Director of the Human Cancer Genetics Program, and Director of the Institute of Genetics at The Ohio State University Comprehensive Cancer Center. His research has revealed the variety of mutated genes involved in leukemias, lymphomas and other cancers. Dr. Croce is world-renowned for his contributions involving the genes and genetic mechanisms implicated in the pathogenesis of human cancer. During the course of his career, he discovered the juxtaposition of the human immunoglobulin genes to the MYC oncogene, the deregulation of MYC in Burkitt lymphoma, the ALL1/MLL gene involved in acute leukemias, the TCL1 gene associated with T-cell leukemias, and cloned, named and characterized the BCL2 gene involved in follicular lymphoma. Dr. Croce has also uncovered the early events involved in the pathogenesis of lung, nasopharyngeal, head and neck, esophageal, gastrointestinal and breast cancers. In 2002 he discovered the role of microRNA in the pathogenesis of human cancer and then demonstrated that microRNA dysregulation contributes to the pathogenesis of all tumors. His discoveries have led to revolutionary innovations in the development of novel and successful approaches to cancer prevention, diagnosis, monitoring and treatment, based on gene-target discovery, verification and rational drug development. He is a member of the National Academy of Sciences, Institute of Medicine (National Academy of Medicine), American Academy of Arts and Sciences, an AAAS Fellow and Fellow of the AACR Academy. He is principal investigator on seven federal research grants and has more than 1000 peer-reviewed, published research papers.