Session date: 
Wednesday, November 9, 2016 - 12:00pm to 1:00pm

Michel Sadelain, MD, PhD

Director, Center for Cell Engineering &

Gene Transfer and Gene Expression

Memorial Sloan-Kettering Cancer Center

Dr. Michel Sadelain is Professor and Director, Center for Cell Engineering at Memorial Sloan Kettering Cancer Center. He completed his MD at The University of Paris in 1984 and his PhD in Immunology at the University of Alberta in 1989. Since 2007, he has held the position of Director at the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center.  His clinical focus is the mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer. The advent of technologies that permit efficient gene transfer in human primary cells reates novel therapeutic perspectives. Based on the use of recombinant oncoretroviruses and lentiviruses, we are investigating how to control transgene expression in vivo in hematopoietic stem cells and how to augment immune responses against tumor cells. Our current studies on the first topic focus on the role of locus control regions and insulators in regulating the transcription of randomly integrated beta globin transgenes. With respect to tumor immunity, we are exploring different strategies to target T cells to tumor cells, either by facilitating dendritic cell-T cell interactions or by enhancing the co-stimulation of T cells that engage tumor cells.

Bluemle Life Sciences Building
233 South 10th Street
Room 101
Philadelphia, PA 19107
United States
Session Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit
  • 1.00 Attendance

Please login or register to take this course.